Heartworm Drug Sensitivity Test

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Barb Wright
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Heartworm Drug Sensitivity Test

Post by Barb Wright »

Wanted to pass this information along....certainly something to ask your vet about before giving Heartworm preventatives.

"New Test for Heartworm Drug Sensitivity.

WSU (Washington State University)'s Veterinary Clinical
Pharmacology Laboratory has developed a gene test for
ivermectin/drug sensitivity that owners/veterinarians can
use to identify dogs that have the mutation BEFORE
administering various drugs that can result in illness and
even death in certain dogs. Individuals then can be treated
with alternative drugs or with dosage adjustments to protect
them. The test identifies those dogs with one copy of the mutant
gene, as well as animal with two normal, or two copies of the
mutant gene. Dogs with one copy of the mutant gene can be
at increased risk of toxicity; dogs with two copies are potentially
in grave danger of toxicity. Dogs with the wild-type (normal) gene
can safely be administered drugs like ivermectin. The dogs with
the mutated gene can be sensitive to other medications as well.

The gene has been dubbed MDR1 for Multiple Drug Resistance
gene #1, and normally produces a protein that pumps various
rugs out of the central nervous system, for example, thus avoiding toxic
build up. Dogs with the mutated gene have a frame-shift mutation that
results in a stop codon & so produces a nonfunctional protein. Various drugs
can then accumulate in the brain & other tissues, resulting in various
neurological and gastrointestinal effects typically. The gene is found
in many herding breeds & is widespread in several breeds: in collies current
studies indicate that less than 1/4 of the population that is free of the
Ivermectin sensitivity is found scattered throughout a number of breeds,
& although it's possible that other mutations are responsible for drug
sensitivties in various breeds, WSU will genotype any dog for the MDR1
For more on the service, email: _vcpl@vetmed.wsu.edu_
(mailto:vcpl@vetmed.wsu.edu) or visit:
_www.vetmedwsu.edu/depts-VCPL_ (http://www.vetmedwsu.edu/depts-VCPL)

Genotype testing offers owners a new opportunity to protect their pets.
Treating individuals according to their individual genotype holds great
promise for the future of what is now being called pharmacogenetics.
testing also allows breeders the information to control the expression
of various traits & so manage disease and limit the spread of various
disease-inducing genes. Permission to repost in entirety for educational
purposes is granted.

Best regards, JP Yousha
Chmn., Health and Welfare, GDCA
_http://www.gdca.org/healthand welfare.htm_
(http://www.gdca.org/healthand welfare.htm)

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